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BioMEMS (Biological Micro-Electro-Mechanical Systems)
Formation of micro-bioreactors
Close up of a cell in a silicon pore
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We work on the formation of micro-bioreactors that both customize cell-surface interactions and allow for efficient mass transfer between cells and a perfused fluid stream. This work is in collaboration with M. Sailor (Chemistry).
The image on the right is a SEM of a rat hepatocyte in a macroscopic silicon pore surrounded by nanoporous silicon for a perfused fluid.
Atomic force micrograph of electrochemically etched holes in a silicon substrate to control cell-ECM interactions for individual hepatocytes
Research Interests
- BioMEMS
Our efforts have focused on the development of microtechnology tools for cell biology research and tissue engineering applications.
- Hepatic Tissue Engineering
We study the effects of the tissue microenvironment on the hepatocyte phenotype in vitro, for applications in cell-based therapies.
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